Further Information
PDGFBB,PDGFB,FLJ12858,PDGF2,SIS,SSV,c-sis
This recombinant protein can be used for E, WB. For research use only.
PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.
- Hoch RV, Soriano P. 2003, Development 130 (20): 4769?4784.
- Olofsson B, et al. 1996, Proc Natl Acad Sci U S A.,93(6):2576-81.
- Joukov V, et al. 1996, EMBO J. 15 (2): 290?298.
- Lei KJ, et al. 1993, Oncogene 8 (4): 925?931.
Measured by its binding ability in a functional ELISA. Immobilized Human PDGF-BB, His Tag at 5 ug/mL (100 ul/well) can bind Human PDGF R beta, Fc Tag with a linear range of 0.02-1.2 ug/mL.
0.085% TFA in 30% ACN
His Tag & Avi Tag
5155
Platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
PDGF-B
Homo sapiens
Lyophilized
Predicted Molecular Weight:
15 kDa
AAH29822
>95% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
E. coli
P01127