NSJ Bioreagents

MyD88 Antibody

Product Code:
 
NSJ-R30745
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
After reconstitution, the MyD88 antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.
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Western blot testing of MyD88 antibody and Lane 1: rat spleen; 2: rat thymus; 3: Jurkat; 4: Raji cell lysate. Predicted molecular weight: 33 kDa~
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IHC-P: MyD88 antibody testing of human tonsil tissue
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Western blot testing of MyD88 antibody and Lane 1: rat spleen; 2: rat thymus; 3: Jurkat; 4: Raji cell lysate. Predicted molecular weight: 33 kDa~
IHC-P: MyD88 antibody testing of human tonsil tissue

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NSJ-R30745-100ug100 ug£535.00
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Further Information

Application Details :
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting points. Titration of the MyD88 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Myeloid differentiation primary response gene 88 is a protein that in humans is encoded by the MYD88 gene. MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors(IL1Rs). It a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 andToll-like receptorsignaling pathways. Qverexpression causes an increase in the level of transcription from the interleukin-8 promoter. The C-terminal domain of the protein has significant sequence similarity to the cytoplasmic domain of IL1RAP. Inhibiting the IL1R-MyD88 pathway in vivo could block the damage from acute inflammation that occurs in response to sterile cell death, and do so in a way that might not compromise tissue repair or host defense against pathogens.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
An amino acid sequence from the middle region of human MyD88 (FVQEMIRQLEQTNYR) was used as the immunogen for this MyD88 antibody.
Limitation:
This MyD88 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse, Rat
Uniprot #:
Q99836