SHP2 Antibody

Western blot: 0.5-1ug/ml

The stated application concentrations are suggested starting amounts. Titration of the SHP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

PTPN11 (Tyrosine-protein phosphatase non-receptor type 11), also known as 'SH2 domain containing protein tyrosine phosphatase 2' (SHP2), is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. The open reading frame consists of 1,779 nucleotides potentially encoding a protein of 593 amino acids with a predicted molecular mass of 68 kD. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP/SHP2 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndromeas well as acute myeloid leukemia.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

An amino acid sequence from the C-terminus of human SHP2 (RVYENVGLMQQQKSFR) was used as the immunogen for this SHP2 antibody.

This SHP2 antibody is available for research use only.

Antigen affinity

Human, Mouse, Rat

Q06124